Prime Minister Mostafa Madbouly said public transport would be halted, and a public curfew would be imposed from 5pm to 6am.
Shops, restaurants, beaches and parks will also be closed, and restrictions on citizens’ movements will stay in place for at least two weeks afterwards.
Madbouly said the measures would protect public health and help to prevent any further spread of the coronavirus.
Over 11,700 cases have been reported in Egypt, along with 612 virus-related deaths.
The government has slightly eased its nightly curfew, despite the daily number of cases continuing to rise.
