Five people were in the vehicle and had just left a nightclub when they were fired on with Kalashnikovs.
Two of those targeted fled the scene, as did the unknown attackers.
Police linked the incident to the drugs trade.
According to AFP news agency, it brings to twenty one, the number of drug-related killings in Marseille so far this year.
The latest shooting happened in a residential area of France’s second-largest city.
