Luis Suarez assisted three goals and scored the other as Barcelona went three points clear of Real Madrid at the top of La Liga.
Antoine Griezmann scored the opener and then Arturo Vidal blasted in a second, before Pere Pons’ header for Alaves.
But Messi smashed home an excellent 25-yard strike and then Suarez scored a penalty following a handball.
Elsewhere, Real Madrid slipped two points behind rivals Barcelona after a goalless draw at home against Athletic Bilbao.
Results:
On Friday,
FT Eibar 3 – 0 Granada
On Saturday,
FT Mallorca 0 – 2 Sevilla
FT Barcelona 4 – 1 Deportivo Alaves
FT Villarreal 1 – 0 Getafe
FT Real Valladolid 1 – 1 Valencia
Yesterday,
FT Leganes 2 – 0 RCD Espanyol
FT Osasuna 3 – 4 Real Sociedad
FT Real Betis 1 – 2 Atletico Madrid
FT Levante 3 – 1 Celta Vigo
FT Real Madrid 0 – 0 Athletic Bilbao
