The Super Eagles began their quest to be at the tournament which will be played in Qatar, with a 2-0 win over Liberia last Friday.
However, Gernot Rohr’s squad was without some key players who are based in the UK, for the trip to Mindelo.
The hosts took a shock lead in the 20th minute through Dylan Tavares.
However, Napoli striker Victor Osimhen made it 1-1 for Nigeria before the break.
With the game heading for a draw, Kenny Santos diverted the ball past his goalkeeper, to hand the three-time African Champions all three points.
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